EZH2-IN-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

EZH2-IN-5 

EZH2-IN-5 是一种有效的 EZH2 抑制剂,对野生型和突变型 Tyr641 EZH2 的 IC50 值分别为 1.52 nM 和 4.07 nM。

EZH2-IN-5

EZH2-IN-5 Chemical Structure

CAS No. : 1403258-69-4

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生物活性

EZH2-IN-5 is a potent EZH2 inhibitor with IC50 values of 1.52 nM and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively[1].

IC50 & Target[1]

EZH2 WT

1.52 nM (IC50)

EZH2 Y641F mutant type

4.07 nM (IC50)

体外研究
(In Vitro)

EZH2-IN-5 (compound 276) inhibits cell growth of WSUDLCL2 cell lines with an IC50 of 187.28 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

517.50

Formula

C26H37BrN4O2

CAS 号

1403258-69-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Richard Chesworth, et al. Substituted benzene compounds. WO2012142513A1

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