A68930

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

A68930 

A68930 作为 dopamine D1 receptor 激动剂，可用于支气管扩张的研究。

A68930

A68930 Chemical Structure

CAS No. : 130465-45-1

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生物活性

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].

IC50 & Target

D1 Receptor

 

体外研究
(In Vitro)

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 16HBE14o- or NCI-H292 cells
Concentration: 1 μM
Incubation Time: 5~60 minutes
Result: Significantly increased phosphorylation of CREB.

RT-PCR[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: Induced MUC5AC mRNA expression.

Immunofluorescence[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.

分子量

271.31

Formula

C16H17NO3
CAS 号

130465-45-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2.

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