ABC99

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ABC99 

BC99 是一种 N-hydroxyhydantoin (NHH) carbamate,选择性抑制 Wnt-deacylating 酶 NOTUM (IC50=13 nM)。BC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。

ABC99

ABC99 Chemical Structure

CAS No. : 2331255-53-7

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生物活性

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].

IC50 & Target

IC50: 13 nM (Notum)[1]

体外研究
(In Vitro)

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner[1].
ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 0.1~10 μΜ
Incubation Time: 2 hours
Result: Inhibited NOTUM in a concentration-dependent manner.

分子量

456.88

Formula

C22H21ClN4O5

CAS 号

2331255-53-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.

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