标签归档：notum

ABC99

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ABC99 

BC99 是一种 N-hydroxyhydantoin (NHH) carbamate，选择性抑制 Wnt-deacylating 酶 NOTUM (IC50=13 nM)。BC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。

ABC99

ABC99 Chemical Structure

CAS No. : 2331255-53-7

规格 价格 是否有货
5 mg ￥4500 询问价格 & 货期
10 mg ￥8000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].

IC50 & Target

IC50: 13 nM (Notum)[1]
体外研究
(In Vitro)

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner[1].
ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 0.1~10 μΜ
Incubation Time: 2 hours
Result: Inhibited NOTUM in a concentration-dependent manner.

分子量

456.88

Formula

C22H21ClN4O5
CAS 号

2331255-53-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ABC99

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ABC99 

BC99 是一种 N-hydroxyhydantoin (NHH) carbamate，选择性抑制 Wnt-deacylating 酶 NOTUM (IC50=13 nM)。BC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。

ABC99

ABC99 Chemical Structure

CAS No. : 2331255-53-7

规格 价格 是否有货
5 mg ￥4500 询问价格 & 货期
10 mg ￥8000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].

IC50 & Target

IC50: 13 nM (Notum)[1]
体外研究
(In Vitro)

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner[1].
ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 0.1~10 μΜ
Incubation Time: 2 hours
Result: Inhibited NOTUM in a concentration-dependent manner.

分子量

456.88

Formula

C22H21ClN4O5
CAS 号

2331255-53-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ABC99

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ABC99 

BC99 是一种 N-hydroxyhydantoin (NHH) carbamate，选择性抑制 Wnt-deacylating 酶 NOTUM (IC50=13 nM)。BC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。

ABC99

ABC99 Chemical Structure

CAS No. : 2331255-53-7

规格 价格 是否有货
5 mg ￥4500 询问价格 & 货期
10 mg ￥8000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].

IC50 & Target

IC50: 13 nM (Notum)[1]
体外研究
(In Vitro)

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner[1].
ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 0.1~10 μΜ
Incubation Time: 2 hours
Result: Inhibited NOTUM in a concentration-dependent manner.

分子量

456.88

Formula

C22H21ClN4O5
CAS 号

2331255-53-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carboxylesterase-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carboxylesterase-IN-2 

Carboxylesterase-IN-2 (compound 4u) 是一种有效的 Carboxylesterase Notum 抑制剂，IC50 小于或等于 10 nM。Notum 是 Wnt 信号传导的负调节剂，通过棕榈油酸酯的水解作用，这是 Wnt 活性所必需的。Carboxylesterase-IN-2具有研究癌症疾病的潜力。

Carboxylesterase-IN-2

Carboxylesterase-IN-2 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease[1].

分子量

272.33

Formula

C13H12N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carboxylesterase-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carboxylesterase-IN-2 

Carboxylesterase-IN-2 (compound 4u) 是一种有效的 Carboxylesterase Notum 抑制剂，IC50 小于或等于 10 nM。Notum 是 Wnt 信号传导的负调节剂，通过棕榈油酸酯的水解作用，这是 Wnt 活性所必需的。Carboxylesterase-IN-2具有研究癌症疾病的潜力。

Carboxylesterase-IN-2

Carboxylesterase-IN-2 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease[1].

分子量

272.33

Formula

C13H12N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carboxylesterase-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carboxylesterase-IN-2 

Carboxylesterase-IN-2 (compound 4u) 是一种有效的 Carboxylesterase Notum 抑制剂，IC50 小于或等于 10 nM。Notum 是 Wnt 信号传导的负调节剂，通过棕榈油酸酯的水解作用，这是 Wnt 活性所必需的。Carboxylesterase-IN-2具有研究癌症疾病的潜力。

Carboxylesterase-IN-2

Carboxylesterase-IN-2 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease[1].

分子量

272.33

Formula

C13H12N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carboxylesterase-IN-3

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carboxylesterase-IN-3 

Carboxylesterase-IN-3 (compound 4y) 是一种有效的 Carboxylesterase Notum 抑制剂，IC50 小于或等于 10 nM。Notum 是 Wnt 信号传导的负调节剂，通过棕榈油酸酯的水解作用，这是 Wnt 活性所必需的。Carboxylesterase-IN-2具有研究癌症疾病的潜力。

Carboxylesterase-IN-3

Carboxylesterase-IN-3 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease[1].

分子量

313.16

Formula

C11H6Cl2N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务