Isobutyl-deoxynyboquinone(Synonyms: IB-DNQ)

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Isobutyl-deoxynyboquinone (Synonyms: IB-DNQ)

Isobutyl-deoxynyboquinone (IB-DNQ) 是 NAD(P)H:quinone oxidoreductase (NQO1) 的选择性底物。Isobutyl-deoxynyboquinone 可用于抗癌研究。

Isobutyl-deoxynyboquinone(Synonyms: IB-DNQ)

Isobutyl-deoxynyboquinone Chemical Structure

CAS No. : 1430798-22-3

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生物活性

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer[1].

体外研究
(In Vitro)

Isobutyl-deoxynyboquinone (0.01~100 μM; OSCC cells) demonstrates greater cytotoxic potency against SCCF1 and SCCF2 cell lines, and less against the SCCF3 cell line. Isobutyl-deoxynyboquinone (0.1~3 μM; 60 minutes; SCCF1 cells) induces cytotoxicity in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Isobutyl-deoxynyboquinone (0.5~2 mg/kg; i.v.; 20 hours) achieves average peak plasma concentration levels. Isobutyl-deoxynyboquinone (1 mg/kg; p.o.; 4 hours) achieves peak plasma concentrations[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cats
Dosage: 0.5~2 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Achieved average peak plasma concentration levels.
Animal Model: Cats
Dosage: 1 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Achieved peak plasma concentration.

分子量

326.35

Formula

C18H18N2O4

CAS 号

1430798-22-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lundberg AP, et al. Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species. Invest New Drugs. 2017;35(2):134-144.

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