NOC-5

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NOC-5 

NOC-5 是一个重氮唑啉化合物,是 NO 的供体。

NOC-5

NOC-5 Chemical Structure

CAS No. : 146724-82-5

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生物活性

NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].

体外研究
(In Vitro)

NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1].
NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

176.22

Formula

C6H16N4O2

CAS 号

146724-82-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.

    [2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802.

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