(Rac)-Shikonin(Synonyms: Shikalkin)

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(Rac)-Shikonin (Synonyms: Shikalkin)

(Rac)-Shikonin (Shikonin) 具有抗肿瘤活性。(Rac)-Shikonin (Shikonin) 通过诱导坏死死亡来绕过癌症耐药性。

(Rac)-Shikonin(Synonyms: Shikalkin)

(Rac)-Shikonin Chemical Structure

CAS No. : 54952-43-1

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生物活性

(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer drug resistance by induction of a necroptotic death[1][2].

体外研究
(In Vitro)

Shikonin shows a similar potency toward drug-sensitive cancer cell lines (MCF-7 and HEK293) and their drug-resistant lines overexpressing P-glycoprotein, Bcl-2, or Bcl-xL, which account for most of the clinical cancer drug resistance[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

288.30

Formula

C16H16O5

CAS 号

54952-43-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. U Sankawa, Antitumor activity of shikonin and its derivatives. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2392-5.

    [2]. Weidong Han, et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther. 2007 May;6(5):1641-9.

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