Wistin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Wistin 

Wistin 可从 Caragana sinica 根部分离得到,是 PPARαPPARγ 的激动剂。

Wistin

Wistin Chemical Structure

CAS No. : 19046-26-5

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生物活性

Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist[1][2].

体外研究
(In Vitro)

Wistin, is a PPARγ agonist that can induce the mRNA expression of the PPARγ target gene adiponectin in mouse 3T3-L1 cells[2].
Wistin inhibits cellular triglyceride accumulation in hepatocytes (P<0.05 at 10 μg/mL) in a dose-dependent manner[2].
Wistin (10 μg/mL) results in a 2.5-, 7.2-, and 14.8-fold increase in the expression levels of CPT1a, ACO, and ACS, respectively[2].
Treatment with Wistin for 48 h significantly decreases the amount of cellular TG in mouse primary hepatocytes in a dose-dependent manner[2].
Treatment with wistin enhanced the marker of adipocyte differentiation, such as triglyceride accumulation in 3T3-L1 cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: Mouse hepatocytes.
Concentration: 1 or 10 μg/mL.
Incubation Time: 48 h.
Result: Significantly increased PPARα mRNA levels in a dose-dependent manner.

分子量

460.43

Formula

C23H24O10

CAS 号

19046-26-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. SeonJu Park, et al. Neuraminidase Inhibitors from the Roots of Caragana sinica. Chem Biodivers. 2020 Nov;17(11):e2000470.

    [2]. Misato Suzuki, et al. 4′,6-Dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes. Mol Cell Biochem. 2018 Sep;446(1-2):35-41.

    [3]. Matoki Sanada, et al. 4′,6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor γ (PPARγ) agonist that stimulates adipocyte differentiation. Anim Sci J. 2016 Nov;87(11):1347-1351.

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