PAO-Nap

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PAO-Nap 

PAO-Nap 是NAP (naphthalimide) 荧光基团修饰的 PAO。PAO 通过选择性靶向硫氧蛋白还原酶诱导 HL-60 细胞氧化应激介导的凋亡。

PAO-Nap

PAO-Nap Chemical Structure

CAS No. : 1613402-20-2

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生物活性

PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].

体外研究
(In Vitro)

PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

509.39

Formula

C24H24AsN3O5

CAS 号

1613402-20-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.

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