Rubropunctatin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Rubropunctatin 

Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎,免疫抑制和抗氧化作用,还具有抗肿瘤活性。

Rubropunctatin

Rubropunctatin Chemical Structure

CAS No. : 514-67-0

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity[1][2][3].

体外研究
(In Vitro)

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1[1].
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells[1].
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: BGC-823 and GES-1cells
Concentration: 1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time: 24 hours
Result: Decreased the viability of BGC-823 cells with an IC50 of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis[1]

Cell Line: BGC-823 cells
Concentration: 0, 5, 10, 30 μM
Incubation Time: 0, 6, 12, 24 hours
Result: Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.

体内研究
(In Vivo)

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice[1].
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (5 weeks) are inoculated with BGC-823 cells[1]
Dosage: 8, 32 mg/kg
Administration: I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result: Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.

分子量

354.40

Formula

C21H22O5

CAS 号

514-67-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zheng Y, et, al. Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Appl Microbiol Biotechnol. 2010 Nov;88(5):1169-77.

    [2]. Dhale MA, et, al. Protective and antioxidative effect of rubropunctatin against oxidative protein damage induced by metal catalyzed reaction. Int J Biol Macromol. 2018 Sep;116:409-416.

    [3]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务