上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
L-733060 hydrochloride
L-733060 hydrochloride 是一种有效的速激肽 NK1 受体拮抗剂。 L-733060 hydrochloride 以不会在啮齿动物中引起不良心血管影响的剂量抑制神经源性血浆外渗,同时还充当抗肿瘤剂。
L-733060 hydrochloride Chemical Structure
CAS No. : 148687-76-7
规格 | 是否有货 | ||
---|---|---|---|
1 mg | 询价 | ||
5 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
L-733060 hydrochloride is a potent tachykinin NK1 receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent[1][2]. |
||||||||
---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1] |
|
||||||||
体外研究 (In Vitro) |
L-733060 (30-300 nM) inhibits the [Ca2+]i mobilisation caused by substance P (100 nM) in a concentration-dependent manner in human tachykinin NK1 receptor-transfected CHO cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
|
||||||||
体内研究 (In Vivo) |
L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||
分子量 |
439.82 |
||||||||
Formula |
C20H20ClF6NO |
||||||||
CAS 号 |
148687-76-7 |
||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务