IVHD-valtrate

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IVHD-valtrate 

IVHD-valtrate 是一种活性Valeriana jatamansi  的衍生物,在体内外对人卵巢癌细胞均有抑制作用。IVHD-valtrate 诱导癌细胞凋亡 (apoptosis),抑制卵巢癌细胞停滞在 G2/M 期。IVHD-valtrate 有潜力成为用于人类卵巢癌研究的一种新的化疗试剂。

IVHD-valtrate

IVHD-valtrate Chemical Structure

CAS No. : 28325-56-6

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生物活性

IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research[1].

IC50 & Target

IC50: apoptosis[1]

体外研究
(In Vitro)

IVHD-valtrate inhibits the growth and proliferation of the A2780 and OVCAR-3 ovarian cancer cell lines in a concentration-dependent manner[1].
IVHD-valtrate results in a relatively low cytotoxicity to immortalized non-tumorigenic human ovarian surface epithelial cells (IOSE-144)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

540.60

Formula

C27H40O11

CAS 号

28325-56-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xiaoguang Li, et al. Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms. Curr Cancer Drug Targets. 2013 May;13(4):472-83.

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