(S)-Verapamil D7 hydrochloride(Synonyms: (S)-(-)-Verapamil D7 hydrochloride)

发表于由

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(S)-Verapamil D7 hydrochloride (Synonyms: (S)-(-)-Verapamil D7 hydrochloride)

(S)-Verapamil D7 hydrochloride ((S)-(-)-Verapamil D7 hydrochloride) 是 (S)-Verapamil hydrochloride 的一种氘代化合物。(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) 通过 MRP1 抑制白三烯 C4 (LTC4) 和钙黄绿素的转运。(S)-Verapamil hydrochloride 导致潜在耐药性肿瘤细胞死亡。

(S)-Verapamil D7 hydrochloride(Synonyms: (S)-(-)-Verapamil D7 hydrochloride)

(S)-Verapamil D7 hydrochloride Chemical Structure

规格 价格 是否有货
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生物活性

(S)-Verapamil D7 hydrochloride ((S)-(-)-Verapamil D7 hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

分子量

498.11

Formula

C27H32D7ClN2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.

    [2]. Tannergren C, et al. St John’s wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

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