TL13-22

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TL13-22 

TL13-22 是 一种 TL13-12 (HY-122582) 的阴性对照，是一种有效的 ALK 抑制剂，IC50 为 0.54 nM。TL13-22 不会降解细胞中的 ALK。

TL13-22

TL13-22 Chemical Structure

CAS No. : 2229036-65-9

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生物活性

TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1].

IC50 & Target

IC50: 0.54 nM (ALK)[1]
体外研究
(In Vitro)

TL13-22 prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 11.3 nM, 5.74 nM, 18.4 nM, and 65.9 nM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

947.50

Formula

C45H55ClN10O9S
CAS 号

2229036-65-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.

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