Budesonide impurity C(Synonyms: 布地奈德杂质C)

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Budesonide impurity C (Synonyms: 布地奈德杂质C)

Budesonide impurity C 是 Budesonide 的一种杂质。Budesonide 是一种吸入型糖皮质类固醇，一种具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。

Budesonide impurity C(Synonyms: 布地奈德杂质C)

Budesonide impurity C Chemical Structure

CAS No. : 1040085-99-1

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生物活性

Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist[1][2].

体外研究
(In Vitro)

Budesonide is selective for human glucocorticoid receptor (hGR; EC50=45.7 pM) over mineralocorticoid receptors (EC50=7,620 pM) in CV-1 cells[1].
Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

430.53

Formula

C25H34O6
CAS 号

1040085-99-1
中文名称

布地奈德杂质C
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40.

    [2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406.

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