Maytansinoid DM4

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Maytansinoid DM4 

Maytansinoid DM4 是一种具有强力细胞毒性的含硫醇美登素衍生物，可用作 ADC 毒性分子。

Maytansinoid DM4

Maytansinoid DM4 Chemical Structure

CAS No. : 799840-96-3

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生物活性

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].

IC50 & Target[1][2]

Maytansinoids

 

体外研究
(In Vitro)

Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

794.39

Formula

C39H56ClN3O10S
CAS 号

799840-96-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

    [2]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.

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