Pip-alkyne-Ph-COOCH3

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Pip-alkyne-Ph-COOCH3 

Pip-alkyne-Ph-COOCH3 是一种基于 alkyl chain的PROTAC linker，可用于合成 ARD-266。

Pip-alkyne-Ph-COOCH3

Pip-alkyne-Ph-COOCH3 Chemical Structure

CAS No. : 2308496-47-9

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生物活性

Pip-alkyne-Ph-COOCH3 is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC ARD-266[1].

IC50 & Target[1]

Alkyl-Chain

 

体外研究
(In Vitro)

ARD-266 is a a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

243.30

Formula

C15H17NO2
CAS 号

2308496-47-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.

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