标签归档：alkyne

Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-5k 5000 Da 100 mg修饰性聚乙二醇

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Alkyne PEG thiol, ALK-PEG-SH

Cat. No. PG2-AKTH-5k Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

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Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-3k 3400 Da 100 mg修饰性聚乙二醇

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Alkyne PEG thiol, ALK-PEG-SH

Cat. No. PG2-AKTH-3k Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-2k 2000 Da 100 mg修饰性聚乙二醇

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Alkyne PEG thiol, ALK-PEG-SH

Cat. No. PG2-AKTH-2k Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-2k 2000 Da 100 mg
Specification 2000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-1k 1000 Da 100 mg修饰性聚乙二醇

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Alkyne PEG thiol, ALK-PEG-SH

Cat. No. PG2-AKTH-1k Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-1k 1000 Da 100 mg
Specification 1000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-600 600 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Alkyne PEG thiol, ALK-PEG-SH

Cat. No. PG2-AKTH-600 Alkyne PEG thiol, ALK-PEG-SH Cat. No. PG2-AKTH-600 600 Da 100 mg
Specification 600 Da
Unit Size 100 mg
Price $485.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Boc-Pip-alkyne-Ph-COOH

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-Pip-alkyne-Ph-COOH 

Boc-Pip-alkyne-Ph-COOH 是一种 PROTAC linker (PROTAC linker)，属于 alkyl/ether 类。Boc-Pip-alkyne-Ph-COOH 可用于合成一系列 PROTAC 分子，如 ARD-266 (HY-133020)。ARD-266 有效诱导雄激素受体 (AR) 阳性 LNCaP，VCaP 和 22Rv1 前列腺癌细胞系中的 AR 蛋白降解，DC50 值为 0.2-1 nM。

Boc-Pip-alkyne-Ph-COOH

Boc-Pip-alkyne-Ph-COOH Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].

IC50 & Target[1]

Alkyl/ether

 

分子量

329.39

Formula

C19H23NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Han X, Zhao L, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.

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Pip-alkyne-Ph-COOCH3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pip-alkyne-Ph-COOCH3 

Pip-alkyne-Ph-COOCH3 是一种基于 alkyl chain的PROTAC linker，可用于合成 ARD-266。

Pip-alkyne-Ph-COOCH3

Pip-alkyne-Ph-COOCH3 Chemical Structure

CAS No. : 2308496-47-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Pip-alkyne-Ph-COOCH3 is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC ARD-266[1].

IC50 & Target[1]

Alkyl-Chain

 

体外研究
(In Vitro)

ARD-266 is a a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

243.30

Formula

C15H17NO2
CAS 号

2308496-47-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Methyltetrazine-PEG5-alkyne

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Methyltetrazine-PEG5-alkyne 

Methyltetrazine-PEG5-alkyne 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Methyltetrazine-PEG5-alkyne

Methyltetrazine-PEG5-alkyne Chemical Structure

CAS No. : 1802907-97-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

402.44

Formula

C20H26N4O5
CAS 号

1802907-97-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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TAMRA-PEG4-Alkyne

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TAMRA-PEG4-Alkyne 

TAMRA-PEG4-Alkyne 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

TAMRA-PEG4-Alkyne

TAMRA-PEG4-Alkyne Chemical Structure

CAS No. : 1225057-68-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

TAMRA-PEG4-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

643.73

Formula

C36H41N3O8
CAS 号

1225057-68-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Alkyne-ethyl-PEG1-Boc(Synonyms: Alkyne-ethyl-PEG1-t-butyl ester)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Alkyne-ethyl-PEG1-Boc (Synonyms: Alkyne-ethyl-PEG1-t-butyl ester)

Alkyne-ethyl-PEG1-Boc 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Alkyne-ethyl-PEG1-Boc(Synonyms: Alkyne-ethyl-PEG1-t-butyl ester)

Alkyne-ethyl-PEG1-Boc Chemical Structure

CAS No. : 2100306-55-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

198.26

Formula

C11H18O3
CAS 号

2100306-55-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Alkyne PEG FITC, ALK-PEG-FITC Cat. No. PG2-AKFC-3k 3400 Da 50 mg修饰性聚乙二醇

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Alkyne PEG FITC, ALK-PEG-FITC

Cat. No. PG2-AKFC-3k
Specification 3400 Da
Unit Size 50 mg
Price $385.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Alkyne PEG hydroxyl, ALK-PEG-OH Cat. No. PG2-AKOH-3k 3400 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Alkyne PEG hydroxyl, ALK-PEG-OH

Cat. No. PG2-AKOH-3k
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PC Alkyne-PEG4-NHS ester

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PC Alkyne-PEG4-NHS ester 

PC Alkyne-PEG4-NHS ester 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

PC Alkyne-PEG4-NHS ester

PC Alkyne-PEG4-NHS ester Chemical Structure

CAS No. : 1802907-98-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

653.63

Formula

C29H39N3O14
CAS 号

1802907-98-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PC Alkyne-PEG4-NHS ester

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PC Alkyne-PEG4-NHS ester 

PC Alkyne-PEG4-NHS ester 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

PC Alkyne-PEG4-NHS ester

PC Alkyne-PEG4-NHS ester Chemical Structure

CAS No. : 1802907-98-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

653.63

Formula

C29H39N3O14
CAS 号

1802907-98-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Alkyne PEG Silane, ALK-PEG-Si Cat. No. PG2-AKSL-3k 3400 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Alkyne PEG Silane, ALK-PEG-Si

Cat. No. PG2-AKSL-3k Alkyne PEG Silane, ALK-PEG-Si Cat. No. PG2-AKSL-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Folate-PEG3-alkyne

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Folate-PEG3-alkyne 

Folate-PEG3-alkyne 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Folate-PEG3-alkyne

Folate-PEG3-alkyne Chemical Structure

CAS No. : 1245285-73-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

610.62

Formula

C28H34N8O8
CAS 号

1245285-73-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Alkyne PEG amine, ALK-PEG-NH2 Cat. No. PG2-AKAM-5k 5000 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Alkyne PEG amine, ALK-PEG-NH2

Cat. No. PG2-AKAM-5k Alkyne PEG amine, ALK-PEG-NH2 Cat. No. PG2-AKAM-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

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Description:

Alkyne functionalized polyethylene glycol (Alk-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Alkyne group can react with azide in aqueous solution catalyzed by copper. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet