Propargyl-PEG4-O-C1-Boc

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Propargyl-PEG4-O-C1-Boc 

Propargyl-PEG4-O-C1-Boc 是一种 PROTAC linker,属于 PEG 类。Propargyl-PEG4-O-C1-Boc 可用于合成一系列 PROTAC 分子。

Propargyl-PEG4-O-C1-Boc

Propargyl-PEG4-O-C1-Boc Chemical Structure

CAS No. : 2098489-63-3

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生物活性

Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

346.42

Formula

C17H30O7

CAS 号

2098489-63-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.

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