Amino-PEG11-amine

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Amino-PEG11-amine  纯度: ≥95.0%

Amino-PEG11-amine 是基于 PEG (12 个单元) 的PROTAC linker，可用于链接基于 DES设计的单体配体，为制备更具选择性和更高活性的雌激素受体拮抗剂用于提供新的方向。

Amino-PEG11-amine

Amino-PEG11-amine Chemical Structure

CAS No. : 479200-82-3

规格 价格 是否有货 数量
50 mg ￥1800 In-stock
100 mg ￥2900 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

544.68

Formula

C24H52N2O11
CAS 号

479200-82-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.

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