Araliadiol

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Araliadiol 

Araliadiol 是从 Aralia cordata Thunb 的叶子中分离出来的一种聚炔化合物。Araliadiol 抑制 MCF-7 细胞生长，IC50 值为 6.41 µg/mL。

Araliadiol

Araliadiol Chemical Structure

CAS No. : 1354638-93-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].

IC50 & Target

IC50: 6.41 µg/mL (MCF-7 cells growth)[1]
体外研究
(In Vitro)

Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1].
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 20 µM, 40 µM, and 80 µM
Incubation Time: 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours
Result: The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %).

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 20 µM, 40 µM, and 80 µM
Incubation Time: 48 hours
Result: Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).

分子量

232.32

Formula

C15H20O2
CAS 号

1354638-93-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cheng WL, et al. Inhibitory effect of human breast cancer cell proliferation via p21-mediated G1 cell cycle arrest by araliadiol isolated from Aralia cordata Thunb. Planta Med. 2011 Jan;77(2):164-8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务