Araliadiol

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Araliadiol 

Araliadiol 是从 Aralia cordata Thunb 的叶子中分离出来的一种聚炔化合物。Araliadiol 抑制 MCF-7 细胞生长，IC50 值为 6.41 µg/mL。

Araliadiol

Araliadiol Chemical Structure

CAS No. : 1354638-93-9

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生物活性

Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].

IC50 & Target

IC50: 6.41 µg/mL (MCF-7 cells growth)[1]
体外研究
(In Vitro)

Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1].
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 20 µM, 40 µM, and 80 µM
Incubation Time: 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours
Result: The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %).

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 20 µM, 40 µM, and 80 µM
Incubation Time: 48 hours
Result: Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).

分子量

232.32

Formula

C15H20O2
CAS 号

1354638-93-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cheng WL, et al. Inhibitory effect of human breast cancer cell proliferation via p21-mediated G1 cell cycle arrest by araliadiol isolated from Aralia cordata Thunb. Planta Med. 2011 Jan;77(2):164-8.

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