Ospemifene D4(Synonyms: FC-1271a D4)

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Ospemifene D4 (Synonyms: FC-1271a D4)

Ospemifene D4 (FC-1271a D4) 是 Pirfenidone 的氘代物。Ospemifene 是一种选择性的口服活性雌激素受体调节剂，可预防骨质疏松，对雌激素受体 α (ERα) 和 ERβ 的 IC50 值分别为 827 nM 和 1633 nM。Ospemifene 具有保骨，抗肿瘤和降低胆固醇的作用。

Ospemifene D4(Synonyms: FC-1271a D4)

Ospemifene D4 Chemical Structure

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生物活性

Ospemifene D4 (FC-1271a D4) is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects[1][2].

IC50 & Target

IC50: 827 nM (estrogen receptor α (ERα)) and 1633 nM (ERβ)[1]
分子量

382.92

Formula

C24H19D4ClO2
中文名称

奥培米芬 D4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Qiang Qv.et al.Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology.Feb;141(2):809-20. 25. (2000).

    [2]. Tracy L. Taras et al.In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology 77(4-5):271-9,(2001).

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