Phthalimide-PEG4-MPDM-OH

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Phthalimide-PEG4-MPDM-OH 

Phthalimide-PEG4-MPDM-OH是一种 PROTAC linker,属于 PEG 类。Phthalimide-PEG4-MPDM-OH 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过 linker 连接的不同配体: 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

Phthalimide-PEG4-MPDM-OH

Phthalimide-PEG4-MPDM-OH Chemical Structure

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生物活性

Phthalimide-PEG4-MPDM-OH is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-MPDM-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

PEGs

 

分子量

436.50

Formula

C22H32N2O7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

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