Phthalimide-PEG3-C2-OTs

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Phthalimide-PEG3-C2-OTs 

Phthalimide-PEG3-C2-OTs (Compound 5) 是一种 PROTAC linker,属于 PEG 类。Phthalimide-PEG3-C2-OTs 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过 linker 连接的不同配体; 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

Phthalimide-PEG3-C2-OTs

Phthalimide-PEG3-C2-OTs Chemical Structure

CAS No. : 382162-12-1

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生物活性

Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

PEGs

 

分子量

477.53

Formula

C23H27NO8S

CAS 号

382162-12-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Stegmaier P, et al. Photoactive branched and linear surface architectures for functional and patterned immobilization of proteins and cells onto surfaces: a comparative study. Chemphyschem. 2009 Feb 2;10(2):357-69.

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