Tephrosin(Synonyms: 灰叶草素; Deguelinol I; Hydroxydeguelin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tephrosin (Synonyms: 灰叶草素; Deguelinol I; Hydroxydeguelin) 纯度: ≥97.0%

Tephrosin 是一种天然类胡萝卜素，具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。

Tephrosin Chemical Structure

CAS No. : 76-80-2

* Please select Quantity before adding items.

Tephrosin 相关产品

生物活性	Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors^[1].
体外研究 (In Vitro)	Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) ^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	410.42
Formula	C₂₃H₂₂O₇
CAS 号	76-80-2
中文名称	灰叶草素
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293(1):23-30.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务