Cytochalasin E(Synonyms: 细胞松弛素E)

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Cytochalasin E (Synonyms: 细胞松弛素E)

Cytochalasin E 是一种含有曲霉衍生真菌代谢产物的环氧化物，抑制血管生成和肿瘤生长，Cytochalasin E 是一种有效的肌动蛋白解聚剂，能结合肌动蛋白丝的倒刺端并盖住，以防止肌动蛋白伸长。

Cytochalasin E(Synonyms: 细胞松弛素E)

Cytochalasin E Chemical Structure

CAS No. : 36011-19-5

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生物活性

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2].

体外研究
(In Vitro)

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3].
Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

495.56

Formula

C28H33NO7
CAS 号

36011-19-5
中文名称

细胞松弛素E
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7.

    [2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83.

    [3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647.

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