Benzthiazide-d7(Synonyms: 苄噻嗪 d7)

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Benzthiazide-d7 (Synonyms: 苄噻嗪 d7)

Benzthiazide-d7 是 Benzthiazide 的氘代物。Benzthiazide 是一种长效的利尿剂和抗高血压剂。Benzthiazide 为碳酸酐酶 9 (carbonic anhydrase 9 (CA9)) 的抑制剂，对 CA9，CA2 和 CA1 的 Ki 值分别为 8.0，8.8 和 10 nM。Benzthiazide 能够抑制肿瘤细胞增殖。

Benzthiazide-d7(Synonyms: 苄噻嗪 d7)

Benzthiazide-d7 Chemical Structure

CAS No. : 1794768-22-1

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生物活性

Benzthiazide-d7 is the deuterium labeled Benzthiazide. Benzthiazide is a long-acting diuretic[1] and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

438.98

Formula

C15H7D7ClN3O4S3
CAS 号

1794768-22-1
中文名称

苄噻嗪 d7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Adler RA, et al. Hypercalciuria in hyperprolactinemic rats: effects of benzthiazide. Metabolism. 1986 Jul;35(7):668-72.

    [3]. Lee HS, et al. Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. BMC Syst Biol. 2012 Jul 2;6:80.

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