Meclizine-d8 dihydrochloride(Synonyms: Meclozine-d8 dihydrochloride)

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Meclizine-d8 dihydrochloride (Synonyms: Meclozine-d8 dihydrochloride)

Meclizine-d8 (Meclozine-d8) dihydrochloride 是 Meclizine dihydrochloride 的氘代物。Meclizine (Meclozine) dihydrochloride 是一种抗组胺剂 (antihistamine)，可逆地抑制组胺与 H1 受体的相互作用。Meclizine dihydrochloride 是哌嗪类 H1 拮抗剂。Meclizine dihydrochloride 是一种有效的抗晕车剂。Mecliz

Meclizine-d8 dihydrochloride(Synonyms: Meclozine-d8 dihydrochloride)

Meclizine-d8 dihydrochloride Chemical Structure

CAS No. : 1432062-16-2

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生物活性

Meclizine-d8 (Meclozine-d8) dihydrochloride is the deuterium labeled Meclizine dihydrochloride. Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington’s disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

471.92

Formula

C25H21D8Cl3N2
CAS 号

1432062-16-2
中文名称

盐酸美克洛嗪 d8 (双盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.

    [3]. Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington’s disease. Hum Mol Genet. 2011 Jan 15;20(2):294-300.

    [4]. Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR

    [5]. Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2(9):1090-101.

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