MC-Sq-Cit-PAB-Dolastatin10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MC-Sq-Cit-PAB-Dolastatin10 

MC-Sq-Cit-PAB-Dolastatin10 是抗体偶联药物的一部分，由管蛋白聚合抑制剂 Dolastatin10 和 ADC linker MC-Sq-Cit-PAB 连接而成。

MC-Sq-Cit-PAB-Dolastatin10

MC-Sq-Cit-PAB-Dolastatin10 Chemical Structure

CAS No. : 1941168-65-5

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生物活性

MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.

IC50 & Target

Auristatin

 

体外研究
(In Vitro)

ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.385 nM, and ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3×2.1 with IC50s of 3.19 nM, 1.52 nM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1338.72

Formula

C70H105N12O12S+
CAS 号

1941168-65-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1.

    [2]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.

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