Rimonabant-d10 hydrochloride(Synonyms: 盐酸利莫那班 d10 (盐酸盐))

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Rimonabant-d10 hydrochloride (Synonyms: 盐酸利莫那班 d10 (盐酸盐))

Rimonabant-d10 (SR 141716A-d10) hydrochloride 是 Rimonabant Hydrochloride 的氘代物。Rimonabant hHydrochloride (SR 141716A Hydrochloride) 是中心大麻素受体 1 (CB1) 高效的、选择性的反向激动剂， Ki 值为1.8 nM。Rimonabant hHydrochloride (SR 141716A Hydrochloride) 也能够抑制分枝杆菌膜蛋白3 (MMPL3)。

Rimonabant-d10 hydrochloride(Synonyms: 盐酸利莫那班 d10 (盐酸盐))

Rimonabant-d10 hydrochloride Chemical Structure

CAS No. : 1044909-61-6

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生物活性

Rimonabant-d10 (SR 141716A-d10) hydrochloride is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

510.31

Formula

C22H12D10Cl4N4O
CAS 号

1044909-61-6
中文名称

盐酸利莫那班 d10 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15.

    [3]. Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13.

    [4]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.

    [5]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.

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