Adenosine-d1(Synonyms: Adenine riboside-d1; D-Adenosine-d1)

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Adenosine-d1 (Synonyms: Adenine riboside-d1; D-Adenosine-d1)

Adenosine-d1 (Adenine riboside-d1) 是 Adenosine 的氘代物。Adenosine (Adenine riboside) 是一种普遍存在的内源性分泌物，是通过四种G蛋白偶联受体（A1、A2A、A2B 和 A3）的起作用。Adenosine 几乎影响细胞生理学的所有方面，包括神经元活动、血管功能、血小板聚集和血细胞调节。

Adenosine-d1(Synonyms: Adenine riboside-d1; D-Adenosine-d1)

Adenosine-d1 Chemical Structure

CAS No. : 109923-50-4

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生物活性

Adenosine-d1 (Adenine riboside-d1) is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

268.25

Formula

C10H12DN5O4
CAS 号

109923-50-4
中文名称

腺苷 d1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323.

    [3]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625.

    [4]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915.

    [5]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838.

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