PROTAC BRD4-binding moiety 1

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PROTAC BRD4-binding moiety 1 

PROTAC BRD4-binding moiety 1 是 BRD4 的配体。PROTAC BRD4-binding moiety 1 通过 linker 结合到 cereblon 配体上形成 PROTAC 以降解 BRD4 (HY-133136)。

PROTAC BRD4-binding moiety 1

PROTAC BRD4-binding moiety 1 Chemical Structure

CAS No. : 2101200-10-4

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生物活性

PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1].

IC50 & Target

BRD4

 

体外研究
(In Vitro)

PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

371.43

Formula

C23H21N3O2
CAS 号

2101200-10-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

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