ABD957

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ABD957 

ABD957 是一种有效和选择性的去棕榈酰酶 ABHD17 家族的共价抑制剂，抑制 IC50 的 IC50 为 0.21 µM。ABD957 可以阻断 N-Ras 信号传导和 NRAS 突变 AML 细胞的生长。

ABD957

ABD957 Chemical Structure

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生物活性

ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells[1].

IC50 & Target

IC50: 0.21 µM (ABHD17B)[1]
体外研究
(In Vitro)

ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells[1].
ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: OCI-AML3, THP1, HL60, NB-4 and NOMO1 cells
Concentration: 0.1, 1, 10, 100, 1000, 10000 nM
Incubation Time: 72 hours
Result: Reduced the growth of NRAS-mutant AML cell lines (OCI-AML3, THP1 and HL60), but not KRAS mutant cell lines (NB-4 and NOMO1).

分子量

627.68

Formula

C27H36F3N7O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Remsberg JR, et, al. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 Aug;17(8):856-864.

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