RB-3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

RB-3 

RB-3 是 PRC1 的抑制剂，结合到 RING1B-BMI1f，其 Kd 值为2.8 μM。

RB-3

RB-3 Chemical Structure

CAS No. : 2396639-11-3

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生物活性

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].

IC50 & Target

Kd: 2.8 μM (RING1B-BMI1f)[1].
体外研究
(In Vitro)

RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1].
RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1].
RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1].
RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: TEX cells.
Concentration: 6, 12, 25 μM.
Incubation Time: 8d.
Result: Dose-dependently increased C/EBPα-p42 protein levels.

分子量

417.89

Formula

C24H20ClN3O2
CAS 号

2396639-11-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.

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