E7766 disodium

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

E7766 disodium 

E7766 disodium 是一种大环桥连 STING 激动剂,Kd 为 40 nM。E7766 disodium 显示出强大的泛基因型和抗肿瘤活性。

E7766 disodium

E7766 disodium Chemical Structure

CAS No. : 2242636-28-6

规格 价格 是否有货
1 mg ¥5800 询问价格 & 货期
5 mg ¥16500 询问价格 & 货期
10 mg ¥26500 询问价格 & 货期

* Please select Quantity before adding items.

E7766 disodium 的其他形式现货产品:

E7766 diammonium salt

生物活性

E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].

体外研究
(In Vitro)

E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

792.58

Formula

C24H26F2N10Na2O8P2S2

CAS 号

2242636-28-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

发表回复