GNE-502

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

GNE-502 

GNE-502 是一种口服有效的雌激素受体 (ER) 降解剂。GNE-502 可用于乳腺癌研究。

GNE-502

GNE-502 Chemical Structure

CAS No. : 1953134-16-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].

IC50 & Target

ER[1]

体内研究
(In Vivo)

GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1].
.. GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 10 and 100 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.

分子量

471.59

Formula

C25H30FN3O3S

CAS 号

1953134-16-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.

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