PROTAC Bcl-xL degrader-2

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PROTAC Bcl-xL degrader-2 

PROTAC Bcl-xL degrader-2 是一种基于 von Hippel-Lindau 配体的 Bcl-xL (Bcl-2 家族成员) 降解剂，IC50 为 0.6 nM。

PROTAC Bcl-xL degrader-2

PROTAC Bcl-xL degrader-2 Chemical Structure

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生物活性

PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM.

IC50 & Target[1]

Bcl-xL

0.6 nM (IC50)

VHL

 

体外研究
(In Vitro)

PROTAC Bcl-xL degrader-2 (PROTAC 6; 0.1 nM-10 μM; 24 hours) treatment decreases the level of Bcl-xL protein in THP-1 cells[1].
PROTAC Bcl-xL degrader-2 (PROTAC 6) inhibits caspase 3/7 activity in MOLT-4 cells with an IC50 of 466 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: THP-1 cells
Concentration: 0.1 nM-10 μM
Incubation Time: 24 hours
Result: Led to monotonic decreases in observed Bcl-xL protein.

分子量

1329.60

Formula

C68H80N8O14S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chun-Wa Chung, et al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

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