BET-IN-6

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BET-IN-6 

BET-IN-6 是一种有效且高亲和力的 BRD2/BRD4 抑制剂。BET-IN-6 可以用作靶蛋白 BRD2/4 的配体，用于合成 PROTAC BRD2/BRD4 degrader-1 (HY-130612)。

BET-IN-6

BET-IN-6 Chemical Structure

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生物活性

BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 degrader-1 (HY-130612)[1].

IC50 & Target

IC50: BRD2/BRD4; ligand for PROTAC[1]
分子量

440.47

Formula

C22H20N2O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

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