Lenalidomide-PEG3-iodine

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Lenalidomide-PEG3-iodine 

Lenalidomide-PEG3-iodine 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Lenalidomide 的 cereblon 配体和 3 个单元的 linker。Lenalidomide-PEG3-iodine 可用于合成一系列 PROTAC 分子，如 SJF620 (HY-133137)。SJF620 是一种 PROTAC BTK 降解剂，DC50 为 7.9 nM。

Lenalidomide-PEG3-iodine

Lenalidomide-PEG3-iodine Chemical Structure

规格 是否有货
25 mg 询价
50 mg 询价

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生物活性

Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). SJF620 is a potent PROTAC BTK degrader consisting of the BTK inhibitor conjugated to Lenalidomide by a linker[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

502.30

Formula

C19H23IN2O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877.

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