EGFR mutant-IN-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR mutant-IN-1

EGFR mutant-IN-1 是一种 5-甲基嘧啶吡啶酮衍生物，是有效的，选择性 EGFR^{L858R/T790M/C797S} 突变抑制剂，IC₅₀ 为 27.5 nM，对 EGFR^WT 的抑制作用明显较低 (IC₅₀ >1.0 μM)。

EGFR mutant-IN-1 Chemical Structure

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生物活性	EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFR^{L858R/T790M/C797S} mutant inhibitor with an IC₅₀ of 27.5 nM, while being a significantly less potent for EGFR^WT (IC₅₀ >1.0 μM)^[1].
IC₅₀ & Target	IC50: 27.5 nM (EGFR^{L858R/T790M/C797S}) and >1.0 μM (EGFR^WT)^[1]
分子量	632.17
Formula	C₃₄H₃₉ClFN₇O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shen J, et al. Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type SparingInhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J Med Chem. 2019 Aug 8;62(15):7302-7308.

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