EGFR mutant-IN-1 | 赛默飞Alfa aesar官网

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EGFR mutant-IN-1

EGFR mutant-IN-1 是一种 5-甲基嘧啶吡啶酮衍生物，是有效的，选择性 EGFR^{L858R/T790M/C797S} 突变抑制剂，IC₅₀ 为 27.5 nM，对 EGFR^WT 的抑制作用明显较低 (IC₅₀ >1.0 μM)。

EGFR mutant-IN-1 Chemical Structure

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生物活性	EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFR^{L858R/T790M/C797S} mutant inhibitor with an IC₅₀ of 27.5 nM, while being a significantly less potent for EGFR^WT (IC₅₀ >1.0 μM)^[1].
IC₅₀ & Target	IC50: 27.5 nM (EGFR^{L858R/T790M/C797S}) and >1.0 μM (EGFR^WT)^[1]
分子量	632.17
Formula	C₃₄H₃₉ClFN₇O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shen J, et al. Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type SparingInhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J Med Chem. 2019 Aug 8;62(15):7302-7308.

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