DC10SMe

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DC10SMe 

DC10SMe 是一种 DNA 烷化剂,可用于合成抗体偶联药物 (ADC)。DC10SMe 对 Ramos,Namalwa 和 HL60/s 癌细胞的 IC50 值分别为 15 pM,12 pM 和 12 pM。

DC10SMe

DC10SMe Chemical Structure

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生物活性

DC10SMe is a DNA alkylator, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC10SMe exhibits IC50s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively[1].

IC50 & Target[1]

Duocarmycins

 

体外研究
(In Vitro)

DC10SMe is a active cyclopropyl form. DC10SMe undergoes N-3 alkylation with an adenine residue and thus form a DNA adduct[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

647.77

Formula

C35H29N5O4S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.

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