Coformycin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Coformycin 

Coformycin 是一种核苷类抗生素,是腺苷脱氨酶 (adenosine deaminase , ADA) 的抑制剂。Coformycin 具有抗肿瘤和抗菌活性。

Coformycin

Coformycin Chemical Structure

CAS No. : 11033-22-0

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生物活性

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

体内研究
(In Vivo)

Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss-Webster mice[2].
Dosage: 0.2 mg/kg.
Administration: IP daily.
Result: Inhibited adenosine deaminase activity for various tissues.

分子量

284.27

Formula

C11H16N4O5

CAS 号

11033-22-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Coformycin.

    [2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.

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