Thalidomide-PEG2-C2-NH2 hydrochloride(Synonyms: Thalidomide-NH-PEG2-C2-NH2 hydrochloride)

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Thalidomide-PEG2-C2-NH2 hydrochloride (Synonyms: Thalidomide-NH-PEG2-C2-NH2 hydrochloride)

Thalidomide-PEG2-C2-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker。

Thalidomide-PEG2-C2-NH2 hydrochloride(Synonyms: Thalidomide-NH-PEG2-C2-NH2 hydrochloride)

Thalidomide-PEG2-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2245697-87-2

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Thalidomide-PEG2-C2-NH2 hydrochloride 的其他形式现货产品:

Thalidomide-PEG2-C2-NH2 TFA

生物活性

Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

440.88

Formula

C19H25ClN4O6
CAS 号

2245697-87-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

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