GSK9311 hydrochloride

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GSK9311 hydrochloride 

GSK9311 hydrochloride 是一种活性较低的 GSK6853 类似物,可用作阴性对照。GSK9311 hydrochloride 抑制 BRPF 溴结构域,对 BRPF1 和 BRPF2 的 pIC50 值分别为 6.0 和 4.3。

GSK9311 hydrochloride

GSK9311 hydrochloride Chemical Structure

CAS No. : 2253733-09-2

规格 是否有货
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GSK9311 hydrochloride 的其他形式现货产品:

GSK9311

生物活性

GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].

IC50 & Target

BRPF1

6.0 (pIC50)

BRPF2

4.3 (pIC50)

体外研究
(In Vitro)

GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

474.00

Formula

C24H32ClN5O3

CAS 号

2253733-09-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

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