上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
ERK-IN-2
ERK-IN-2 是 ERK2 抑制剂探针， IC50 值为 1.8 nM。 ERK-IN-2 的使用剂量 >10 μM 可能导致脱靶毒性和/或脱靶活性。
ERK-IN-2 Chemical Structure
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
ERK-IN-2 is a ERK2 inhibitor probe with an IC50 value of 1.8 nM. ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM[1]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
The criteria of inhibitor probe: Inhibitor potency: goal is <100 nm (ic50); Selectively with target family: >30-fold. We recommend ERK-IN-2 (MRK-ERKi) to be used at a concentration of 1 μM in cell-based experiments and do not recommend doses >10 μM to be employed in any experiment.ERK-IN-2 (1 μM) has effects on cell proliferation in cancer cell lines. The IC50 values are 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
ERK-IN-2 (1 mpk; orally administation/0.5 mpk; intravenous injection) shows a DMPK value: h/r/d LM CLint: <17>1/2: 0.4 h; rat F:13% in SD rat[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
347.80 |
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| Formula |
C16H18ClN5O2 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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