BAY-784

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BAY-784 

BAY-784 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂探针，对人和大鼠 GnRH-R 的 IC50 分别为 21 和 24 nM。

BAY-784

BAY-784 Chemical Structure

CAS No. : 1631164-24-3

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生物活性

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].

IC50 & Target

IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1]
体内研究
(In Vivo)

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OVX rats[1]
Dosage: 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration: Single p.o.
Result: ED50=4.5 mg/kg (4/8 h).
The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.

分子量

672.11

Formula

C29H26ClF4N3O5S2
CAS 号

1631164-24-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. GnRH-R Antagonist Probe BAY-784.

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