AlbA-DCA

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AlbA-DCA 

AlbA-DCA 是一种缀合物,是通过 Albiziabioside A (AlbA) 连接至二氯乙酸 (DCA) 亚基形成的。AlbA-DCA 可以诱导细胞内 ROS 显着增加,并减轻乳酸在肿瘤微环境中的积累,还可以选择性杀死癌细胞并诱导凋亡。

AlbA-DCA

AlbA-DCA Chemical Structure

CAS No. : 2413716-79-5

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生物活性

AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A (AlbA) to a dichloroacetate acid (DCA) subunit. AlbA-DCA can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in tumor microenvironment (TME), and also selectively kills cancer cells and induce apoptosis[1].

IC50 & Target

ROS[1]

体外研究
(In Vitro)

AlbA-DCA exhibits the cytotoxicity against the MCF-7 cells, HCT116 cells, A375 cells, 4T1 cells, HBMEC cells and LO2 cells with IC50 values of 0.43 μM, 3.87 μM, 3.78 μM, 1.31 μM, 38.20 μM and 53.14 μM, respectively[1].
AlbA-DCA (2 μM; 24 hours; MCF-7 cells) treatment induces apoptotic cell death in MCF-7 cells[1].
AlbA-DCA (2 μM; MCF-7 cells) treatment could significantly up-regulate the expression of cytochrome c and down-regulate the expression of antiapoptotic protein Bcl-2. AlbA-DCA significantly enhances the expression of caspase-9[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2 μM
Incubation Time: 24 hours
Result: Induced apoptosis of MCF-7 cells.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2 μM
Incubation Time:
Result: Could significantly up-regulate the expression of cytochrome c and down-regulate the expression of antiapoptotic protein Bcl-2. Significantly enhanced the expression of caspase-9.

体内研究
(In Vivo)

AlbA-DCA (2 mg/kg; subcutaneous injection; every 2 days; for 2 weeks; nude mice) treatment displays antitumor efficacy and almost completely suppresses tumor progression, and no mouse deaths and no significant changes in body weight are observed. AlbA-DCA has no obvious toxicity of liver and kidney and no major abnormality is observed in heart, liver, spleen, lung, and kidney[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing MCF-7 tumors[1]
Dosage: 2 mg/kg
Administration: Subcutaneous injection; every 2 days; for 2 weeks
Result: Displayed the best antitumor efficacy and almost completely suppressed tumor progression.

分子量

860.90

Formula

C43H67Cl2NO12

CAS 号

2413716-79-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wei G, et al. Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy. J Med Chem. 2019 Oct 10;62(19):8760-8772.

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