SS28

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SS28 

SS28是具有口服生物利用度的SRT501 类似物，可抑制微管蛋白聚合，在G2/M引起细胞周期阻滞。SS28会引起细胞凋亡而不是坏死。

SS28

SS28 Chemical Structure

CAS No. : 141172-08-9

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生物活性

SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1].

IC50 & Target

Tubulin[1].
体外研究
(In Vitro)

SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines[1].
SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.
Concentration: 1, 5, 10 and 20 μM.
Incubation Time: 48 and 72 h.
Result: CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48 h of the treatment. IC50 values of SS28 in CEM and A549 cell line were 2.6 and 5.2 μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21 μ M, respectively after 48 h of treatment.

Cell Cycle Analysis[1]

Cell Line: CEM and A549 cells.
Concentration: 2 μM (CEM) and 5 μM (A549).
Incubation Time: 6, 12, 18, 24 and 30 h.
Result: Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24 h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30 h in case of A549. Similarly, studies in CEM also showed a distinct G2/M arrest after 12 h of treatment, as compared to vehicle control.

体内研究
(In Vivo)

SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice using EAC cells[1].
Dosage: 15 mg/kg.
Administration: Orally on every alternate day for 9 doses.
Result: There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.

分子量

284.35

Formula

C18H20O3
CAS 号

141172-08-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Thomas E, et al. A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells. Sci Rep. 2016 Oct 17;6:34653.

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