Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

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Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride 

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride (Cereblon Ligand-Linker Conjugates 10 TFA) 结合了 E3 连接酶配体和 linker,可作为免疫调节剂研究癌症。

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2376990-30-4

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生物活性

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

498.91

Formula

C21H27ClN4O8

CAS 号

2376990-30-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.

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