(S,R,S)-AHPC-PEG3-propionic acid

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(S,R,S)-AHPC-PEG3-propionic acid 

(S,R,S)-AHPC-PEG3-propionic acid 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。

(S,R,S)-AHPC-PEG3-propionic acid

(S,R,S)-AHPC-PEG3-propionic acid Chemical Structure

CAS No. : 2140807-42-5

规格 是否有货
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生物活性

(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

VHL

 

分子量

662.79

Formula

C32H46N4O9S

CAS 号

2140807-42-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

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